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Neuroendocrine Tumors


Definition Neuroendocrine Tumors


Neuroendocrine tumor refers to the type of cell that a tumor grows from rather than where that tumor is located. Neuroendocrine cells produce hormones or regulatory proteins, and so tumors of these cells usually have symptoms that are related to the specific hormones that they produce.

Description Neuroendocrine Tumors


Neuroendocrine cells have roles both in the endocrine system and the nervous system. They produce and secrete a variety of regulatory hormones, or neuropeptides, which include neurotransmitters and growth factors. When these cells become cancerous, they grow and overproduce their specific neuropeptide. Neuroendocrine tumors are generally rare. One type of neuroendocrine tumor is a carcinoid tumor. This type of tumor can occur in the intestinal tract, appendix, rectum, bronchial tubes, or ovary. Most carcinoid tumors secrete serotonin. When the blood concentration of this hormone is high enough, it causes carcinoid syndrome. This syndrome refers to a variety of symptoms that are caused by the excessive amount of hormone secreted rather than the tumor itself. (Islet Cell Neuroendocrine Tumor, Treatment Neuroendocrine Tumor, Gep Multiple Neuroendocrine Tumor)


Causes and Symptoms Neuroendocrine Tumors


Many of the symptoms of carcinoid tumor are due to the hormones that the tumor secretes. These hormones can affect the whole body and cause what is referred to as carcinoid syndrome. The most common symptom of carcinoid syndrome is flushing, a sudden appearance of redness and warmth in the face and neck that can last from minutes to hours. Other symptoms of carcinoid syndrome are diarrhea, asthma-like symptoms and heart problems. Since most carcinoid tumors are found in the appendix, the symptoms are often similar to appendicitis, primarily pain in the abdomen. When these tumors are found in the small intestine, they can cause abdominal pain that is often initially diagnosed as bowel obstruction. Many patients have no symptoms and the carcinoids are found during routine endoscopy of the intestines. (Islet Cell Neuroendocrine Tumor, Treatment Neuroendocrine Tumor, Gep Multiple Neuroendocrine Tumor)

Diagnosis Neuroendocrine Tumors


The diagnosis of carcinoid syndrome is made by the measurement of 5-hydroxy indole acetic acid (5-HIAA) in the urine. 5-HIAA is a breakdown (waste) product of serotonin. If the syndrome is diagnosed, the presence of carcinoid tumor is a given. When the syndrome is not present, diagnosis may be delayed, due to the vague symptoms present. Diagnosis can sometimes take up to two years. It is made by performing a number of tests, and the specific test used depends on the tumor's suspected location. The tests that may be performed include gastrointestinal endoscopy, chest x ray, computed tomography scan (CT scan), magnetic resonance imaging, or ultrasound. A biopsy of the tumor is performed for diagnosis. A variety of hormones can be measured in the blood as well to indicate the presence of a carcinoid. (Islet Cell Neuroendocrine Tumor, Treatment Neuroendocrine Tumor, Gep Multiple Neuroendocrine Tumor)

Treatment Neuroendocrine Tumors


The only treatment for carcinoid tumor is surgical removal of the tumor. Although chemotherapy is sometimes used when metastasis has occurred, it is rarely effective. The treatment for carcinoid syndrome is typically meant to decrease the symptoms. Patients should avoid stress as well as foods that bring on the syndrome. If this does not work, there are a few medications that can help alleviate the symptoms. (Islet Cell Neuroendocrine Tumor, Treatment Neuroendocrine Tumor, Gep Multiple Neuroendocrine Tumor)

Prognosis Neuroendocrine Tumors


The prognosis of carcinoid tumors is related to the specific growth patterns of that tumor, as well as its location. For localized disease the five-year survival rate can be 94%, whereas for patients where metastasis has occurred, the average five-year survival rate is 18%. (Islet Cell Neuroendocrine Tumor, Treatment Neuroendocrine Tumor, Gep Multiple Neuroendocrine Tumor)

Prevention Neuroendocrine Tumors


Neuroendocrine tumors such as carcinoid tumors are rare, and no information consequently is yet available on cause or prevention.

Key Terms

Appendicitis
Inflammation of the appendix.

Growth factor
A local hormone produced by some cells that initiates growth.

Metastasis
The spread of disease from one part of the body to another, as when cancer cells appear in parts of the body remote from the site of the primary tumor.

Neurotransmitter
A chemical messenger used to transmit information in the nervous system. (Islet Cell Neuroendocrine Tumor, Treatment Neuroendocrine Tumor, Gep Multiple Neuroendocrine Tumor)

Neuroendocrine Tumor | Islet Cell Neuroendocrine Tumor | Treatment Neuroendocrine Tumor | Gep Multiple Neuroendocrine Tumor


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